Erectile Dysfunction Drugs

Medications for the treatment of erectile dysfunction are divided into two groups natural remedies and synthetic medicines. The first group most often represent dietary supplements that have not passed clinical trials.

Many consumers do not even know that they are taking pills that have not proven their effectiveness in restoring erection. However, natural products will not necessarily be harmful or low quality; many of them actually work.

The method of administration for medication therapy includes:

  • tablets for oral administration;
  • ointments and creams for local administration;
  • injection drugs that should be injected into the penis.

By the term mechanism of action these drugs include the following:

  • Phosphodiesterase 5 inhibitors (PDE5). It is the most common type of ED drugs on the market. The unreadable substance “phosphodiesterase” is an enzyme that gives the capillaries a command for compression. When the vessels of the penis constrict, the blood can no longer flow inwards, making it hard. These drugs block the enzyme that stops an erection;
  • Nitric oxide synthase activators that act directly on the blood vessels cause them to relax and let the blood flow;
  • Synthetic prostaglandin E analogues
  • Alpha blockers. These drugs are prescribed exclusively by a doctor and have many contraindications. The mechanism of action is similar to the first type because they disable receptors that respond to the release of adrenaline. Most often taken in diabetes, hypertension, disorders of the heart.
  • Hormonal drugs that contain testosterone. They should be taken on a daily basis and only after passing tests;
  • Homeopathic remedies

Testosterone medications.

The appointment of an additional reception of this male hormone is necessary in cases with confirmed diagnosis of decreased testosterone levels in the body. Hormone therapy requires medical supervision because an imbalance of hormone levels leads to harmful consequences. Doctors prescribe testosterone medications in causes of obesity, hypercholesterolemia, age-related decrease, diabetes.

Prostaglandin E

Prostaglandin E medicines positively affect the smooth muscles of the internal organs. Therefore, they have a wide range of applications and are used not only to normalize the sexual function in men but also in the treatment of gynecological diseases, gastrointestinal tract, etc.
Most often in the case of erectile dysfunction doctors prescribe Alprostadil in the form of injection.

Alprostadil improves peripheral blood circulation, dilates blood vessels, including in the cavernous bodies of the penis. This drug has not received widespread use in the treatment of erectile dysfunction, as it is administrated into the sexual organ by injection after which the excretion of urine with blood is possible.

Nitric oxide synthase activator

Homeopathic remedies are agents of this group. The main indications for use are erectile dysfunction, fatigue, decreased physical and emotional activity. The effect of these remedies is to stimulate the production of endothelial nitric oxide synthase antibodies.

The process restores the production of nitric oxide, therefore, improves blood flow in the cavernous bodies of the penis, which in turn increases the strength of erection. Nitric oxide synthase activators don’t raise blood pressure compared with Cialis and Viagra.

Alpha blockers

The most popular medication of this group is Yohimbine, which contains the Yohimbe tree bark extract. In the pharmaceutical industry, it is used as a potent aphrodisiac and dietary supplement for athletes and men with erectile dysfunction.

The alkaloids contained in the bark of the tree have a pronounced effect on the central nervous system: they release nerve centers that are directly responsible for sexual arousal.

The extract solution has a similar effect on women with reduced libido. But in men, its effect is more noticeable in the ensuing erection.

Herbs and natural remedies for erectile dysfunction

Natural remedies, which include natural components that have a beneficial effect on the erectile process. Thanks to natural substances, they can increase libido without side effects, eliminating personal intolerance to the components.

The beneficial effect on erectile function have extracts are ginseng, eleutherococcus senticosus, pantocrin, lemongrass, etc.

Phosphodiesterase 5 inhibitors

Currently, the best drugs for the treatment of erectile dysfunction are phosphodiesterase type 5 inhibitors. These include Viagra, Cialis, and Levitra.


Viagra appeared in 1998 for the first time in the market of pharmacological products and caused a real sensation because it solved the problem of erectile dysfunction almost instantly. To date, the drug is still popular and thoroughly studied.

Therefore, we can safely talk about the positive and negative sides of Viagra on men’s health, because it was taken by men of different ages with various indicators of the physical and psychological state of the body.
The active substance of Viagra is sildenafil citrate, which, according to the initial plans of Pfizer pharmacologists, should be salvation for hypertensive patients and people suffering from angina pectoris.

But during tests, it turned out to be useless for the treatment of heart diseases. However, the drug had one significant side effect – an improved erection, which was extremely dangerous for cardiac patients.

Therefore, the pharmaceutical company continued research, carried out relevant tests and presented to the public a revolutionary “blue pill,” which became a kind of “emergency help” for men over 18 years old.


Cialis is the second contender for the best drug for erection in men. Tadalafil is the active ingredient of the drug, and its task is to activate the production of 3-, 5-cyclic guanosine monophosphate (GMP), which level is lowered in erectile dysfunction.

Tadalafil inhibits the enzyme that breaks down GMP so that become possible to have a strong erection. The effect occurs in 15-25 minutes and lasts as much as 36 hours. It almost has no effect on the cardiovascular system and is better tolerated by the body in general.

Contraindications: myocardial infarction within the last 90 days, ischemic stroke within the previous 180 days, unstable angina, arterial hypotension, lactose deficiency or acute intolerance. Side effects occur in less than 1% of patients. The most frequent of them are palpitations, tachycardia, low blood pressure, pressure


The third equally popular medication for the treatment of erectile dysfunction is Levitra. The success of sexual intercourse is guaranteed by active substance vardenafil, which was obtained with the specific purpose to improve erection.

The creators of the drug took into account the side effects of the precursors (Viagra and Cialis), so the adverse impact of the drug on the liver and kidneys is minimized.

As an inhibitor of a new generation, the blocking enzyme phosphodiesterase-5 (the cause of erectile dysfunction), Levitra exceeds the effect of Viagra.

Even though each of these drugs is available without a prescription, the reception should be approved by the doctor, due to the individual characteristics of the body.